Fetal plasma erythropoietin in pregnancies complicated by maternal diabetes mellitus
作者： Douglas R. Salvesen , J. Michael Brudenell , Rosalinde J.M. Snijders , Robin M. Ireland , Kypros H. Nicolaides
DOI: 10.1016/S0002-9378(12)90891-1
关键词: Endocrinology 、 Erythroblast 、 Erythropoiesis 、 Hyperinsulinemia 、 Diabetes mellitus 、 Fetal hemoglobin 、 Fetus 、 Internal medicine 、 Erythropoietin 、 Hemoglobin 、 Medicine 、 Obstetrics and gynaecology
摘要: Objective: Our purpose was to investigate the relationship between fetal plasma erythropoietin concentration and measures of short-term long-term glycemic control oxygenation in pregnancies complicated by maternal diabetes mellitus. Study Design: A cross-sectional study performed at The Harris Birthright Research Centre for Fetal Medicine, London. Cordocentesis 31 diabetic measurement umbilical venous blood pH, Po 2 , Pco lactate glucose concentration, erythroblast count, hemoglobin, concentrations. Results: mean pH significantly lower lactate, erythropoietin, counts were higher than appropriate normal gestation. There significant associations betwen (1) (2) count (3) hemoglobin glycosylated (4) glucose, lactate. Conclusions: We postulate that hyperglycemia causes acidemia. Increased may be caused tissue hypoxia or hyperinsulinemia. increase consequence increased erythropoiesis, mediated either
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