Insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia

摘要: Polycythaemia in the neonate is a serious pathologic entity which occurs particularly infants of diabetic mothers (IDM) and small-for-gestational age (SGA) infants. Both these conditions are associated with fetal hyperinsulinaemia. Cultures cord blood mononuclear cells from polycythaemic IDM showed increased growth late erythroid progenitor colonies, compared to non-polycythaemic infants, reflecting possible expansion this population fetus. No changes were observed early populations. Biosynthetic human insulin at physiological levels characteristic stimulated culture progenitors premature, term Three out five had elevated plasma C-peptide birth, whereas no infant haematocrit less than 65% high measurements. These data suggest that polycythaemia noted may be secondary, large part, stimulatory effect on by hyperinsulinaemic environment they develop utero.