Heparan sulfate proteoglycan-mediated entry pathway for charged tri-platinum compounds: differential cellular accumulation mechanisms for platinum.
作者： Heveline Silva , Frédéric Frézard , Erica J. Peterson , Peyman Kabolizadeh , John J. Ryan
DOI: 10.1021/MP300098T
关键词: Pinocytosis 、 Heparan sulfate 、 Endocytosis 、 Internalization 、 Receptor 、 Chemistry 、 Chinese hamster ovary cell 、 Cisplatin 、 Biochemistry 、 Chondroitin sulfate 、 Cell biology
摘要: We examined the mechanism of accumulation of charged polynuclear platinum complexes (PPCs) based on analogy of polyarginine interactions with the cell surface heparan sulfate …
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