Induction of Expressions of c-fos and c-myc Protooncogenes by Basic Calcium Phosphate Crystal: Effect of β-Interferon
作者： W. Jackson Pledger , Herman S. Cheung , Peter G. Mitchell
DOI:
关键词: Transcription (biology) 、 Platelet-derived growth factor receptor 、 c-Fos 、 DNA synthesis 、 Calcium 、 Cell cycle 、 Stimulation 、 Biology 、 Growth factor 、 Molecular biology
摘要: Basic calcium phosphate (BCP) crystals control the traverse of cells from G-G1 to S-phase cell cycle and initiate proliferation by rendering fibroblasts competent respond insulin-like growth factors in plasma. The present study examines whether BCP induce transcription protooncogenes c- fos myc effect β-interferon (IFN-β) on protooncogene as well crystal-induced DNA synthesis. Stimulation density-arrested BALB/c-3T3 with either crystal or platelet-derived factor (PDGF) results maximal accumulation mRNA at 30 min after stimulation. Induction PDGF occurs within 1 h is around 3 stimulation. Simultaneous addition IFN-β had little induction but delayed both message entry into S phase. delay treatment cannot account for observed onset synthesis, since can be added up 6 stimulation crystals, a similar synthesis still observed.
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