Effect of hypothermia on the in vitro potencies of neuromuscular blocking agents and on their antagonism by neostigmine

摘要: The effect of temperature on the potencies neuromuscular blocking agents remains unclear. This study was undertaken to examine effects different at 37 and 27 °C a constant carbon dioxide content (α stat principle). neostigmine 1 μmol litre−1 induced antagonism these also investigated. Phrenic nerve-hemidiaphragm preparations rats were mounted in modified Krebs solution, maintained CC aerated with 5% dioxide-95% oxygen gas mixture, 4% maintain solution constant. nerves stimulated 0.1 -Hz supra-maximal impulses 0.2-ms duration elicited tension diaphragm recorded. steroidal (rocuronium, vecuronium, pancuronium pipecuronium) increased significantly (P