Acute and Chronic Manifestations

摘要: Three patients with organophosphate insecticide poisoning are described. The first patient Diazinon@ and the second parathion illustrate acute manifestations, criteria for diagnosis, treatment pralidoxime atropine in poisoning. diagnosis of is based on a history exposure to organophosphates, manifestations including miosis fasciculations, improvement following administration (increased tolerance atropine), reduction blood cholinesterase activity. Pralidoxime has been effective management many by methyl parathion, smaller number Diazinon, EPN, DFP, TEPP; probably Bidrin, carbophenthion, dichlorvos dimethoate; possibly mevinphos. effectiveness man malathion, demeton, phosphamidone azinphosmethyl not established. reactivating organophosphate-inhibited at cholinergic synapses, central nervous system. third polyneuropathy illustrates possibility persistent He had exposed as chemist organophosphates their intermediates, which appear be cause polyneuropathy. In animal experiments some caused man, frequently triorthocresyl phosphate less often mipafox, but rarely commercially available insecticides, cause-result relationship other main effect system symptoms, usually follow inconsistently mainly emotion’al origin.