作者: Becky Tu-Sekine , Daniel M. Raben
DOI: 10.1002/JCP.21813
关键词: Gene isoform 、 Kinase 、 Cell 、 Protein primary structure 、 Biochemistry 、 Diacylglycerol kinase 、 Diglyceride 、 Phosphatidic acid 、 Cell biology 、 Lipid signaling 、 Biology
摘要: Diacylglycerol kinases are important regulators of lipid signaling and, consequently, many diglyceride-dependent and PA-dependent proteins. Research over the last twenty years has clearly demonstrated that individual DGK isoforms can be connected with disparate cellular processes, indicating presence a sophisticated regulatory network for diglyceride phosphatidic acid through regulation isoforms. This review presents progress on characterization primarily neuronal isoform DGK-θ, examines current data primary structure, potential functions this enzyme. J. Cell. Physiol. 220: 548–552, 2009. © 2009 Wiley-Liss, Inc.