Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model

作者: Qiwen Deng , Bangshun He , Xian Liu , Jin Yue , Houqun Ying

DOI: 10.1186/S12967-015-0409-0

关键词: OncologyCarcinogenesisTumor progressionImmunologyInternal medicineLymphocyteMonocyteCancerInflammationNeutrophil to lymphocyte ratioProportional hazards modelMedicine

摘要: Background Inflammation plays an integral role in carcinogenesis and tumor progression. Inflammatory response biomarkers have shown to be promising prognostic factors for improving the predictive accuracy various cancers. The aim of this study is investigate significance pre-operative neutrophil lymphocyte ratio (NLR), derived (dNLR), platelet (PLR) monocyte (LMR) gastric cancer (GC).

参考文章(51)
J. Cadranel, A. Bellocq, B. Crestani, L. Baud, J. F. Bernaudin, C. Philippe, M. Antoine, C. Mayaud, Bernard Milleron, Antoine Flahault, Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. American Journal of Pathology. ,vol. 152, pp. 83- 92 ,(1998)
Mi Ran Jung, Young Kyu Park, Oh Jeong, Jang Won Seon, Seong Yeob Ryu, Dong Yi Kim, Young Jin Kim, Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer Journal of Surgical Oncology. ,vol. 104, pp. 504- 510 ,(2011) , 10.1002/JSO.21986
S. M. Scholl, C. Pallud, F. Beuvon, K. Hacene, E. R. Stanley, L. Rohrschneider, R. Tang, P. Pouillart, R. Lidereau, Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis Journal of the National Cancer Institute. ,vol. 86, pp. 120- 126 ,(1994) , 10.1093/JNCI/86.2.120
Alberto Mantovani, Tiziana Schioppa, Chiara Porta, Paola Allavena, Antonio Sica, Role of tumor-associated macrophages in tumor progression and invasion. Cancer and Metastasis Reviews. ,vol. 25, pp. 315- 322 ,(2006) , 10.1007/S10555-006-9001-7
Kay Washington, 7th Edition of the AJCC Cancer Staging Manual: Stomach Annals of Surgical Oncology. ,vol. 17, pp. 3077- 3079 ,(2010) , 10.1245/S10434-010-1362-Z
Patricia Solomon, Kelly O'Brien, Seanne Wilkins, Nicole Gervais, Aging with HIV and disability: The role of uncertainty Aids Care-psychological and Socio-medical Aspects of Aids\/hiv. ,vol. 26, pp. 240- 245 ,(2014) , 10.1080/09540121.2013.811209
Keunwook Lee, Hyekyung Hwang, Ki Taek Nam, Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer. Gut and Liver. ,vol. 8, pp. 131- 139 ,(2014) , 10.5009/GNL.2014.8.2.131
JUNLING ZHANG, PENGYUAN WANG, JING ZHU, WEI WANG, JIE YIN, CHI ZHANG, ZIYI CHEN, LIE SUN, YUANLIAN WAN, XIN WANG, GUOWEI CHEN, YUCUN LIU, SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells. Oncology Reports. ,vol. 31, pp. 2312- 2320 ,(2014) , 10.3892/OR.2014.3118