The expression and biological information analysis of miR-375-3p in head and neck squamous cell carcinoma based on 1825 samples from GEO, TCGA, and peer-reviewed publications.
作者： Wei-ning Cen , Jin-shu Pang , Jia-cheng Huang , Jia-yin Hou , Wen-guang Bao
DOI: 10.1016/J.PRP.2018.09.010
关键词: Oncology 、 Information analysis 、 Head and neck squamous-cell carcinoma 、 Receiver operating characteristic 、 Internal medicine 、 Biology 、 Clinical significance 、 Peer review 、 Curve analysis 、 Mir-375 、 Disease
摘要: Abstract Background The specific expression level and clinical significance of miR-375-3p in HNSCC had not been fully stated, as well the overall biological function molecular mechanisms. Therefore, we purpose to carry out a comprehensive meta-analysis further explore potential mechanism HNSCC. Methods HNSCC-related data was gained from Gene Expression Omnibus (GEO), Cancer Genome Atlas (TCGA), peer-reviewed journals. A carried comprehensively relationship between clinicopathological features And summary receiver operating characteristic (SROC) curve analysis applied for evaluating disease diagnosis value miR-375-3p. In addition, pathway also performed assess possible Results total 24 available records references were added into analysis. pooled outcome revealed relatively lower specimens than that non-cancerous controls (P Conclusion MiR-375-3p clearly decreased samples compared with controls. Meanwhile, may serve tumor suppressor via regulating tumor-related genes LAMC1, EDIL3, FN1, VEGFA, IGF2BP2, IGF2BP3
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