Arsenic‐Containing Long‐Chain Fatty Acids in Cod‐Liver Oil: A Result of Biosynthetic Infidelity?
作者： Alice Rumpler , John S. Edmonds , Mariko Katsu , Kenneth B. Jensen , Walter Goessler
关键词: Methanol 、 High-performance liquid chromatography 、 Hexane 、 Electrospray ionization 、 Mass spectrometry 、 Homologous series 、 Arsenic 、 Fraction (chemistry) 、 Chemistry 、 Chromatography
摘要: tioned between hexane and aqueous methanol, the polar phase subjected to preparative chromatography with sizeexclusion anion-exchange media yield a fraction enriched in arsenolipids. Analysis of this by HPLC–inductively coupled plasma mass spectrometry (ICPMS) revealed presence at least 15 arsenolipids (Figure 2). Further investigation HPLC– electrospray ionization MS (ESI-MS), under conditions that provided simultaneous detection elemental arsenic molecular masses, [3] showed six major arsenicals (A–F Figure 2) had following masses: A 334, B 362, C 390, D 418, E 388, F 436. The spectral data for four these compounds (A–D) were consistent homologous series arsenic-containing saturated fatty acids type (CH3)2As(O)-(CH2)nCOOH (n = 12, 14, 16, 18) dimethylarsinoyl group,
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