Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long-Term Alcohol Abstinence

摘要: Background While the acute alcohol withdrawal syndrome has been well characterized both in human clinical studies and experimental animals, much less is known regarding long-term affective disturbances that can sometimes persist during protracted abstinence. Nevertheless, since relapse often occurs long after detoxification may be predicted by persistent disruption, a better understanding of behavioral consequences prior dependence lead to improved strategies for prevention. Methods Male female Withdrawal Seizure-Prone Seizure-Resistant mice from second selection replicate (WSP-2, WSR-2) were exposed 10-day chronic-intermittent ethanol vapor protocol (CIE) or plain air then tested repeatedly on sucrose preference test (SPT), marble burying (MBT), light-dark box (LDT) over 7 weeks (forced) Results WSP WSR differed significantly tests anxiety-like behavior (LDT, MBT), we found little evidence disruption following CIE either line. The major exception was LDT, but not displayed longer latencies enter light compartment relative air-controls. Conclusions Selective breeding severity resulted differences between mice. In contrast, however, genes contributing convulsions appear have overlap with those predisposing