Off-label uses of topical vitamin D in dermatology: a systematic review.

摘要: Background: Topical vitamin D is approved by the US Food and Drug Administration for treatment of psoriasis but also used off-label in a variety cutaneous diseases despite lack evidence-based guidelines. Objective: The objective this study was to provide clinical guidelines use topical dermatologic disease. Methods: A systematic literature review conducted via MEDLINE, Embase, CENTRAL databases uses analogues disease other than psoriasis. data were synthesized, evidencebased recommendations rendered according highest level evidence available. Results: total 165 articles met inclusion criteria. moderate strong recommendation given combination with corticosteroids phototherapy vitiligo as monotherapy various ichthyoses, morphea, pityriasis alba, prurigo nodularis, polymorphous light eruption. There showing that ineffective actinic keratosis, seborrheic lichen planus, dermatitis, alopecia areata, chemotherapy-induced alopecia, hypertrophic scars. Conclusion: have an important role disease, higher quality studies are still required.