Emerging role of microRNAs in prostate cancer: implications for personalized medicine.

摘要: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression. Recent findings indicate miRNAs dysregulated in human tumors, suggesting a potential role for these molecules the pathogenesis of cancer. Thus far, only limited number studies have investigated miRNA expression prostate Results from profiles may distinguish carcinoma non-neoplastic specimens and further classify tumors according to androgen dependence. In addition, prognostic significance was attributed specific as predictors clinical recurrence following radical prostatectomy. For handful miRNAs, which widespread dysregulation cancer consistently found, functional investigation has been pursued experimental models establish rationale development miRNA-based therapies. A better understanding exerted by progression is needed, precise definition their targets relevant disease. However, based on available findings, possible management novel biomarkers new therapeutic or intervention tools can be envisioned.