Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

作者: Alexander L Dent , Arthur L Shaffer , Xin Yu , David Allman , Louis M Staudt

DOI: 10.1126/SCIENCE.276.5312.589

关键词: STAT6Transcription factorCytokineCancer researchBCL6Transcription (biology)Gene expressionGerminal centerSignal transductionBiology

摘要: The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis …

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