Lung Structure-Function Relationships

摘要: The characteristic physiologic abnormality that defines chronic obstructive pulmonary disease (COPD) is a decrease in the maximal expiratory flow. Mead and his associates [1] developed concept during forced expiration lateral pressures at points within airways become equal to pleural pressure driving flow from alveoli these approximates static recoil of lung. This means can be reduced by (1) loss lung elasticity, (2) an increase resistance upstream points, and/or (3) compliance downstream points. Over past 15 years we have collected data on function structure more than 400 patients who had surgical resection or lobe. Despite remarkably uniform smoking duration intensity narrow age distribution show wide variation degree airway obstruction. purpose this chapter examine factors determine attempt define relative importance elastic peripheral obstruction reduction