Proteinuria after renal transplantation affects not only graft survival but also patient survival.

摘要: Background. Proteinuria is associated with an increased risk of renal failure. Moreover, proteinuria death in patients diabetes mellitus or hypertension and even the general population. Methods. One year after transplantation, we studied influence presence on either graft failure all 722 recipients a kidney our center who survived at least 1 functioning graft. was analyzed both as categorical variable (presence versus absence) continuous (quantification 24 hr urine). Other variables included this analysis were: donor/recipient age gender, original disease, race, number HLA-A HLA-B mismatches, previous transplants, postmortal living related transplantation year. At included: proteinuria, serum cholesterol, creatinine, blood pressure, use antihypertensive medication. Results. In Cox proportional hazards analysis, (both variable) important independent influencing endpoints. The censored for showed no interaction any other variables. There adverse effect rate (RR=2.03). disease. glomerulonephritis, hypertension, systemic diseases disease significantly increasing amount ratio patient significant, there significant (RR=1.98). almost twice high compared without proteinuria. also amounts Both risks cardiovascular noncardiovascular were increased. Conclusion. increases death.