Biomarkers in molecular epidemiology studies for health risk prediction

作者: Stefano Bonassi , William W Au

DOI: 10.1016/S1383-5742(02)00003-0

关键词: BiologyMolecular epidemiologyRisk analysisHealth risk assessmentEnvironmental diseaseIntensive care medicineGene mutationPublic healthDiseaseGeneticsBiomarker (medicine)Health, Toxicology and Mutagenesis

摘要: The field of molecular epidemiology is very promising, as sophisticated techniques are being developed to address etiology, genetic susceptibility and mechanisms for induction disease. use biomarkers plays a key role in these investigations because the information can be used predict development disease implement prevention programs. However, emphasized by Frederica P. Perera, strewn with studies either that failed validated or whose designs did not adequately consider biology endpoints, availability health risk still limited. In this review, we have briefly described usefulness certain documentation exposure early biological effects, special concern prediction cancer. An emphasis placed on understanding significance biomarkers. By building reliable biomarker databases, promising future integration from genome programs expand scientific frontiers environmental

参考文章(75)
F.P. Perera, D.L. Tang, J.P. O'Neill, W.L. Bigbee, R.J. Albertini, R. Santella, R. Ottman, W.Y. Tsai, C. Dickey, L.A. Mooney, K. Savela, K. Hemminki, HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts Carcinogenesis. ,vol. 14, pp. 969- 973 ,(1993) , 10.1093/CARCIN/14.5.969
E. Gebhart, H. Kappauf, Bleomycin and sister-chromatid exchange in human lymphocyte chromosomes☆ Mutation Research\/genetic Toxicology. ,vol. 58, pp. 121- 124 ,(1978) , 10.1016/0165-1218(78)90104-0
P Schulte, L F Mazzuckelli, Validation of biological markers for quantitative risk assessment. Environmental Health Perspectives. ,vol. 90, pp. 239- 246 ,(1991) , 10.1289/EHP.90-1519476
Dan H. Moore, James D. Tucker, Irene M. Jones, Richard G. Langlois, Pavel Pleshanov, Irena Vorobtsova, Ronald Jensen, A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points. Radiation Research. ,vol. 148, pp. 463- 475 ,(1997) , 10.2307/3579324
SA Salama, SZ Abdel-Rahman, CH Sierra-Torres, FA Hamada, William W Au, None, Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity. Pharmacogenetics. ,vol. 9, pp. 735- 743 ,(1999) , 10.1097/00008571-199912000-00008
N. Rothman, S. Wacholder, N.E. Caporaso, M. Garcia-Closas, K. Buetow, J.F. Fraumeni, The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. Biochimica et Biophysica Acta. ,vol. 1471, ,(2001) , 10.1016/S0304-419X(00)00021-4
D. Pinkel, J. Landegent, C. Collins, J. Fuscoe, R. Segraves, J. Lucas, J. Gray, Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 9138- 9142 ,(1988) , 10.1073/PNAS.85.23.9138
Peter G Shields, Curtis C Harris, Molecular Epidemiology and the Genetics of Environmental Cancer JAMA: The Journal of the American Medical Association. ,vol. 266, pp. 681- 687 ,(1991) , 10.1001/JAMA.1991.03470050081027
R.K Ross, M.C Yu, B.E Henderson, J.-M Yuan, G-S Qian, J-T Tu, Y.-T Gao, G.N Wogan, J.D Groopman, Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma The Lancet. ,vol. 339, pp. 943- 946 ,(1992) , 10.1016/0140-6736(92)91528-G
M T Smith, L Zhang, Biomarkers of leukemia risk: benzene as a model. Environmental Health Perspectives. ,vol. 106, pp. 937- 946 ,(1998) , 10.1289/EHP.98106S4937