Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression

摘要: Kang H, An H-J, Song J-Y, Kim T-H, Heo J-H, Ahn D-H & G (2012) Histopathology 61, 576–586 Notch3 and Jagged2 contribute to gastric cancer development glandular differentiation associated with MUC2 MUC5AC expression Aims:  Notch signalling plays diverse roles in malignant tumours as well normal tissue development. In this study we investigated the expression of pathway genes their clinicopathological significance carcinomas. Methods results:  Notch1, Notch3, Jagged1, Hes1 were analysed by quantitative real-time polymerase chain reaction (qRT–PCR) (n = 81) immunohistochemistry (n = 103) carcinomas. also assessed, using only. With qRT–PCR, Jagged1 increased significantly tumour compared (P < 0.001, P = 0.002, P = 0.008 P < 0.001, respectively). Overexpression Notch3 was intestinal-type carcinomas (P = 0.024) better histological (P = 0.047), respectively. Immunohistochemistry showed a reverse correlation between or (P = 0.033 P = 0.005, respectively) (P = 0.004 gene overexpression related favourable outcome on univariate (P = 0.046 P = 0.042, multivariate (P = 0.045, Notch3) analysis. Conclusions:  The is not only but intestinal/glandular carcinoma cells, suggesting role possible prognostic indicator.