Quinazoline alpha-adrenoreceptor blockers as an adjunct cancer treatment: From bench to bedside
作者： Liam King , David Christie , Wendy Dare , Nijole Bernaitis , Russ Chess-Williams
DOI: 10.1016/J.EJPHAR.2020.173831
关键词: Quinazoline 、 Radiation therapy 、 Chemotherapy 、 Medicine 、 Drug repositioning 、 Alpha (ethology) 、 Bioinformatics 、 Cancer 、 Alpha blocker 、 Adjunct
摘要: Drug repurposing has been increasingly used by both researchers and clinicians to identify new cancer treatments. The alpha-1 adrenoreceptor blockers are a class of drugs that have for many years in the treatment hypertension benign prostatic hyperplasia. Some this class, notably quinazoline derivatives, found display cytotoxic properties, identifying them as potential options cancer. This review will examine currently available evidence investigates anti-cancer properties these agents, mechanisms behind how fit within current therapies. It aims answer question whether agents can go from laboratory bench top into clinics.
sci-hub.st 参考文章(49)
Natasha Kyprianou, Cynthia M. Benning, Suppression of Human Prostate Cancer Cell Growth By α1-Adrenoceptor Antagonists Doxazosin and Terazosin via Induction of Apoptosis Cancer Research. ,vol. 60, pp. 4550- 4555 ,(2000)
C. Cal, R. Uslu, G. Gunaydin, C. Ozyurt, S.B. Omay, Doxazosin: a new cytotoxic agent for prostate cancer? BJUI. ,vol. 85, pp. 672- 675 ,(2001) , 10.1046/J.1464-410X.2000.00607.X
Nicholas R. Lemoine, Rita Lopes, José M.. Arencibia, Ana Bonnin, Mónica López-Barahona, Mónica Del Rio, Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. International Journal of Oncology. ,vol. 27, pp. 1617- 1623 ,(2005) , 10.3892/IJO.27.6.1617
Natasha Kyprianou, Cynthia M Benning, Quinazoline-derived α1-Adrenoceptor Antagonists Induce Prostate Cancer Cell Apoptosis Via an α1-Adrenoceptor-independent Action Cancer Research. ,vol. 62, pp. 597- 602 ,(2002)
Robert Fuchs, Anika Stracke, Nadine Ebner, Christian Wolfgang Zeller, Anna Maria Raninger, Matthias Schittmayer, Tatjana Kueznik, Markus Absenger-Novak, Ruth Birner-Gruenberger, The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P Toxicology. ,vol. 338, pp. 17- 29 ,(2015) , 10.1016/J.TOX.2015.09.008
Ssu-Chia Lin, Shih-Chieh Chueht, Che-Jen Hsiao, Tsia-Kun Li, Tzu-Hsuan Chen, Cho-Hwa Liao, Ping-Chiang Lyu, Jih-Hwa Guh, Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle Neoplasia. ,vol. 9, pp. 830- 839 ,(2007) , 10.1593/NEO.07475
Robert Fuchs, Ingeborg Stelzer, Helga S. Haas, Gerd Leitinger, Konrad Schauenstein, Anton Sadjak, The α1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells Annals of Hematology. ,vol. 88, pp. 989- 997 ,(2009) , 10.1007/S00277-009-0704-Z
WAYNE J.G. HELLSTROM, RUN WANG, CRAIG A. PETERSON, JOHN C. VARADY, NEIL GESUNDHEIT, SURESH C. SIKKA, EFFECTS OF ALPROSTADIL AND PRAZOSIN ON MOTILITY, VIABILITY AND MEMBRANE INTEGRITY OF HUMAN SPERM The Journal of Urology. ,vol. 159, pp. 1559- 1562 ,(1998) , 10.1097/00005392-199805000-00041
Steve Morgan, Paul Grootendorst, Joel Lexchin, Colleen Cunningham, Devon Greyson, The cost of drug development: A systematic review Health Policy. ,vol. 100, pp. 4- 17 ,(2011) , 10.1016/J.HEALTHPOL.2010.12.002
NATASHA KYPRIANOU, JUAN P. LITVAK, ANDREW BORKOWSKI, RICHARD ALEXANDER, STEPHEN C. JACOBS, INDUCTION OF PROSTATE APOPTOSIS BY DOXAZOSIN IN BENIGN PROSTATIC HYPERPLASIA The Journal of Urology. ,vol. 159, pp. 1810- 1815 ,(1998) , 10.1016/S0022-5347(01)63162-8