Serum PSA after anatomic radical prostatectomy. The Johns Hopkins experience after 10 years

摘要: 1. With an average follow-up of 53 months (range 12-120 months), 19.4% (185/955) men have had a cancer recurrence after radical prostatectomy for clinically localized prostate cancer. A detectable serum PSA was the only evidence in 11.2%, whereas 2.2% locally and 6% with distant metastases. 2. The actuarial status at 10 years 70% undetectable PSA; 23% isolated elevation only; 7% metastases; 4% local recurrence. 3. In our study, no patient demonstrated disease progression (local or distant) without PSA. 4. likelihood elevated increased increasing clinical stage, Gleason score, preoperative concentration, pathologic stage. 5. rate tumors score 7 not statistically different from lesions 8-10. 6. There exist marked differences recurrence-free probabilities low ( = 7) when there is pathologically established capsular penetration. 7. Patients concentrations greater than 10.0 ng/mL are risk 8. Men who within first year surgery significantly higher those measurable postoperative two three. 9. 25% harboring occult However, radiation therapy produces sustained suppression to levels 2 more 10% men. This suggests that effective sterilizing residual tumor many 10. Valuable information concerning can be obtained through early measurement article demonstrates long-term value as measure anatomic prostatectomy.