Microvascular Complications of Impaired Glucose Tolerance

摘要: Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both large- small-vessel vascular complications, independent patient’s progression to diabetes. Patients with IGT are at significantly increased risk death morbidity due myocardial infarction, stroke, large-vessel occlusive disease. is more predictive cardiovascular than impaired fasting glucose, probably because it better surrogate resistance. also independently associated traditional microvascular complications diabetes, including retinopathy, renal disease, polyneuropathy, which topics this review. Inhibition nitric oxide-mediated vasodilation, endothelial injury release free fatty acids adipocytokines from adipocytes, direct metabolic end-organ cells contribute complications. Early detection allows intensive diet exercise modification, has proven effective drug therapy in normalizing postprandial inhibiting To what degree intervention will limit recognized not known.