78 – Impaired Glucose Regulation and Neuropathy

摘要: Type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) affects a considerably larger, but unknown, population group. The development of peripheral neuropathy is the most common complication T2DM. Several observational studies indicate that IGT fasting are also associated with neuropathy. This chapter addresses spectrum regulation (IGR), pathophysiology IGR neuropathy, clinical presentation's relationship to physiology Definitions for each these disorders based on venous glucose, or values following an oral test. constitutes metabolic can result in There several pathways injury diabetic nervous system include dysregulation induced by syndrome, oxidative stress, failure nitric oxide (NO) regulation, activation advanced glycation end-products (AGE), dysfunction certain key signaling pathways. Modulation NO may have detrimental effects endothelial function neuronal survival. Reactive oxygen species (ROS) alter mitochondrial function, protein, DNA structure; interfere pathways; deplete antioxidant defenses. AGE formation reactive activated and, turn, regulate signal transduction