Dotmp kit formulations for radioisotopes

作者: R. Keith Frank , Kelli R. Jay , Jaime Simon

DOI:

关键词: Pharmaceutical drugDrugDrug formulationsBone marrow suppressionChemistryBone painChromatographyPharmaceutical formulation

摘要: This invention relates to a Kit formulation prepare radioactive, bone-seeking, pharmaceutical drug that has high radiochemical purity (RCP) in fast, facile and reproducible process. The at least two vials part buffer system with instructions on how make the radiopharmacy. formulations of this can be conveniently reproducibly prepared better delivery mammals, for use treating mammal having bone pain, one or more calcific tumors needing marrow suppression.

参考文章(13)
Kent R. Thoelke, Alan R. Fritzberg, Mark D. Hylarides, Lauren Marie Tatalick, Paul G. Abrams, James Kyle Bryan, Elizabeth K. John, High dose radionuclide complexes for bone marrow treatment ,(2008)
Gene Jamieson, Jardin Michael Des, Clark Allphin, Sigridur Olafsdottir, Pharmaceutical compositions of clonazepam and methods of use thereof ,(2007)
David A. Wilson, Joseph R. Garlich, Jaime Simon, David E. Troutner, Macrocyclic aminophosphonic acid complexes, their formulations and use ,(1989)
Tapas Das, Sudipta Chakraborty, P.R Unni, Sharmila Banerjee, Grace Samuel, H.D Sarma, Meera Venkatesh, M.R.A Pillai, 177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliation. Applied Radiation and Isotopes. ,vol. 57, pp. 177- 184 ,(2002) , 10.1016/S0969-8043(02)00104-5
Jaime Simon, David A Wilson, Wynn A Volkert, David E Troutner, William F Goeckeler, Organic amine phosphonic acid complexes for the treatment of calcific tumors International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. ,vol. 17, ,(1985) , 10.1016/0883-2897(90)90141-M
R. Keith Frank, Jaime Simon, Kenneth Mcmillan, Joseph R. Garlich, Radiopharmaceutical formulations, their method of administration and process of preparation ,(1991)
William F. Goeckeler, David A. Wilson, Wynn A. Volkert, Jaime Simon, David E. Troutner, Radio labeled organic amine phosphonic acid complexes for the treatment of calcific tumors ,(1990)
Xiaoyuan Chen, Michael G. Rosenblum, Multimodality molecular imaging with therapeutic conjugates ,(2009)
Dorla Mirejovsky, Michael Burkhart, Aqueous ifosfamide composition ,(2002)