Interaction of the opiate and NMDA systems in a spatial learning task
作者： Kathleen E. McKay , Nan Min , Regan Fong , Elizabeth Bostock
DOI: 10.3758/BF03327158
关键词: Neurotransmission 、 (+)-Naloxone 、 NMDA receptor 、 Opiate 、 Drug interaction 、 Developmental psychology 、 Long-term potentiation 、 Pharmacology 、 Naltrexone 、 Antagonist 、 Psychology
摘要: Two experiments were done to determine whether opiate and NMDA systems interact influence learning in rats. Experiment 1 examined the effects of coadministration naloxone with MK-801 on acquisition a radial maze task. produced an impairment extending beyond drug administration. Naloxone, alone or combination MK-801, had no effect. 2 tested naltrexone plus-maze Naltrexone A three-way interaction (MK-801 × days) was found, whereby antagonized during period administration but deficit following this period. This suggests that receptors are important for acquisition, opiates is either time limited secondary acquisition.
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