Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5.

摘要: This paper reports a series of 5 experiments concerned with possible role for N-methyl-D-aspartate (NMDA) receptors in certain types learning. The results show that chronic intraventricular infusion the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (D,L- AP5) caused an impairment spatial but not visual discrimination learning rats. Such selectivity occurred despite widespread distribution drug throughout CNS. AP5 sometimes disturbance sensorimotor function during learning, one experiment addressing whether this could be responsible established it was statistically independent. Another showed did affect retention previously acquired information. These behavioral effects were all obtained concentration that, final study, found to sufficient block hippocampal long-term potentiation (LTP) vivo without affecting normal synaptic transmission. Taken together, these observations (1) implicate and (2) extend recent work showing saturation LTP causes anterograde amnesia (McNaughton et al., 1986). A preliminary report parts has been published (Morris 1986a).