The Life Cycle of the Kidney: Implications for CKD

作者: Robert L. Chevalier

DOI: 10.1681/ASN.2014040380

关键词: Renal functionKidneyMuscle hypertrophyUrologyKidney VolumeInternal medicineMedicineGlomerular hyperfiltrationKidney developmentEndocrinologyNephronAlbuminuria

摘要: The growing prevalence of CKD across the world has intensified search for factors responsible progressive loss kidney function over time. In 1980s, Brenner et al. reported that reduced nephron number results in glomerular hyperfiltration and hypertrophy, leading to maladaptive further

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