Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia

摘要: Patients with recurrent apnoeas exhibit autonomic abnormalities manifested as persistent increase in sympathetic nerve activity (SNA). Several studies suggest that chronic intermittent hypoxia (CIH) resulting from is a major stimulus for evoking morbidity. Although it has been proposed CIH, by way of activating the chemoreceptor reflex, leads to excitation, underlying mechanisms are incompletely understood. Studies on experimental models have provided new insights into associated CIH-evoked sympathoexcitation. The purpose this article highlight recent information systemic, cellular and molecular analysis effects CIH chemoreceptor-mediated Chronic exerts two reflex: (a) augmentation carotid body effector responses acute hypoxia; (b) induction long-lasting activation both sensor persists several hours after termination CIH. Available evidence indicates may facilitate processing afferent at central nervous system. Recent reactive oxygen species-mediated signalling mechanism, transcriptional hypoxia-inducible factor-1 one critical sympathoexcitation