Mechanism of Sympathetic Activation and Blood Pressure Elevation in Humans and Animals Following Acute Intermittent Hypoxia

摘要: Sleep apnea is associated with repeated episodes of hypoxemia, causing marked increase in sympathetic nerve activity and blood pressure. Considerable evidence suggests that intermittent hypoxia (IH) resulting from the primary stimulus for overactivity sleep patients. Several IH protocols have been developed either animals or humans to investigate mechanisms underlying altered autonomic regulation circulation. Most these involve several days (10-40 days) exposure, is, chronic (CIH). Recent data suggest a single session acute (AIH), already capable increasing tonic output (sympathetic long-term facilitation, LTF) altering chemo- baroreflexes without elevation This indicates alters neurocirculatory at very early time point, although this neuroplasticity not explored detail. The purpose chapter briefly review effects AIH on LTF alteration reflexes comparison studies CIH studies. We will also discuss potential central peripheral mechanism LTF.