A new HILIC-MS/MS method for the simultaneous analysis of carbidopa, levodopa, and its metabolites in human plasma.
作者： Raquel de Oliveira Vilhena , Flávia Lada Degaut Pontes , Breno Maurício Marson , Rômulo Pereira Ribeiro , Katherine Athayde Teixeira de Carvalho
DOI: 10.1016/J.JCHROMB.2014.06.030
关键词: Electrospray ionization 、 Chemistry 、 Chromatography 、 Formic acid 、 Carbidopa/levodopa 、 Protein precipitation 、 Levodopa 、 Carbidopa 、 Therapeutic drug monitoring 、 Ammonium formate
摘要: … LC–MS/MS was developed for the simultaneous determination of carbidopa, levodopa, and its metabolites (3-o-methyldopa (3-OMD) and dopamine (DOPA… and 20 ng/mL for DOPA. The …
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