Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma.
作者： S. Suematsu , M. Hibi , T. Sugita , M. Saito , M. Murakami
DOI: 10.1007/978-3-642-75889-8_2
关键词: Chemistry 、 Plasmacytoma 、 Gene rearrangement 、 Progenitor cell 、 Growth factor 、 Myeloma protein 、 Molecular biology 、 Haematopoiesis 、 Antibody 、 Interleukin 6
摘要: Interleukin 6 (IL-6) was originally identified as a B cell differentiation factor (BCDF/BSF2) which induces final maturation of cells into antibody producing (Hirano et al 1986). However, subsequent studies with recombinant molecules revealed that IL-6 has wide variety biological functions on various tissues and (Kishimoto 1989). As shown in Fig. 1, acts not only but also hematopoietic progenitors hepatocytes is involved hematopoiesis acute phase reactions. It nerve cells, epidermal keratinocytes kidney mesangium cells. One the most interesting activities induction growth myeloma/plasmacytoma potent for myelomas/plasmacytomas 0.002 ng/ml rIL-6 could induce 50% maximum proliferation human myeloma line (Muraguchi 1988). This concentration 100-fold less than required immunoglobulin
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