Calcium‐sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth
作者： Hui Hui , Damian McHugh , Meredith Hannan , Fanning Zeng , Shang-Zhong Xu
DOI: 10.1113/JPHYSIOL.2005.102889
关键词: Neuronal calcium sensor-1 、 Calcium 、 Cell biology 、 Calcium in biology 、 Transient receptor potential channel 、 Calcium-binding protein 、 Biology 、 TRPC5 、 Neurite 、 Biochemistry 、 Calcium signaling
摘要: The calcium- and sodium-permeable transient receptor potential channel TRPC5 has an inhibitory role in neuronal outgrowth but the mechanisms governing its activity are poorly understood. Here we propose a mechanism involving calcium sensor-1 (NCS-1) protein. Inhibitory mutants of NCS-1 enhance neurite similarly. Mutant does not inhibit surface-expression generally suppresses activity, irrespective whether it is evoked by carbachol, store depletion, lanthanides or elevated intracellular calcium. same protein complex rat brain directly binds to C-terminus. data suggest protein–protein interaction between TRPC5, involvement this retardation outgrowth.
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