In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels – mirage or pot of gold?

作者: Robin S Bon , David J Beech

DOI: 10.1111/BPH.12274

关键词:

摘要: The primary purpose of this review is to address the progress towards small molecule modulators of human T ransient R eceptor P otential C anonical proteins ( TRPC1 , TRPC3 , …

参考文章(93)
Grigori Y. Rychkov, Gregory J. Barritt, Expression and Function of TRP Channels in Liver Cells Advances in Experimental Medicine and Biology. ,vol. 704, pp. 667- 686 ,(2011) , 10.1007/978-94-007-0265-3_35
Hui Hui, Damian McHugh, Meredith Hannan, Fanning Zeng, Shang-Zhong Xu, Saeed-ul-Hassan Khan, Robert Levenson, David J. Beech, Jamie L. Weiss, Calcium‐sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth The Journal of Physiology. ,vol. 572, pp. 165- 172 ,(2006) , 10.1113/JPHYSIOL.2005.102889
H Schleifer, B Doleschal, M Lichtenegger, R Oppenrieder, I Derler, I Frischauf, TN Glasnov, CO Kappe, C Romanin, K Groschner, Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca2+ entry pathways British Journal of Pharmacology. ,vol. 167, pp. 1712- 1722 ,(2012) , 10.1111/J.1476-5381.2012.02126.X
Mohamed S Amer, Lynn McKeown, Sarka Tumova, Ruifeng Liu, Victoria AL Seymour, Lesley A Wilson, Jacqueline Naylor, Katriona Greenhalgh, Bing Hou, Yasser Majeed, Paul Turner, Alicia Sedo, David J O'Regan, Jing Li, Robin S Bon, Karen E Porter, David J Beech, Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma‐1 receptor ligands British Journal of Pharmacology. ,vol. 168, pp. 1445- 1455 ,(2013) , 10.1111/BPH.12041
Y Majeed, MS Amer, AK Agarwal, L McKeown, KE Porter, DJ O'Regan, J Naylor, CWG Fishwick, K Muraki, DJ Beech, Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids British Journal of Pharmacology. ,vol. 162, pp. 1509- 1520 ,(2011) , 10.1111/J.1476-5381.2010.01136.X
Hong-Tao Ma, Ze Peng, Takaaki Hiragun, Shoko Iwaki, Alasdair M. Gilfillan, Michael A. Beaven, Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line Journal of Immunology. ,vol. 180, pp. 2233- 2239 ,(2008) , 10.4049/JIMMUNOL.180.4.2233
Christian Harteneck, Henning Frenzel, Robert Kraft, N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovascular Drug Reviews. ,vol. 25, pp. 61- 75 ,(2007) , 10.1111/J.1527-3466.2007.00005.X
A Singh, ME Hildebrand, E Garcia, TP Snutch, None, The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels British Journal of Pharmacology. ,vol. 160, pp. 1464- 1475 ,(2010) , 10.1111/J.1476-5381.2010.00786.X
G. RAMANATHAN, S. GUPTA, I. THIELMANN, I. PLEINES, D. VARGA-SZABO, F. MAY, C. MANNHALTER, A. DIETRICH, B. NIESWANDT, A. BRAUN, Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets. Journal of Thrombosis and Haemostasis. ,vol. 10, pp. 419- 429 ,(2012) , 10.1111/J.1538-7836.2011.04596.X
D. J. Beech, K. Muraki, R. Flemming, Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP The Journal of Physiology. ,vol. 559, pp. 685- 706 ,(2004) , 10.1113/JPHYSIOL.2004.068734