Effect of polychlorinated biphenyls on the immune responses of rhesus monkeys and mice

作者: Peter T. Thomas , Ronald D. Hinsdill

DOI: 10.1016/0041-008X(78)90282-X

关键词: ChloracneSpleenToxoidTetanusInternal medicineAntibody titerImmunityImmune systemEndocrinologyGamma globulinBiology

摘要: Abstract Female rhesus monkeys were fed either normal chow or containing 2.5 5.0 ppm of Aroclor 1248 (PCB). After 6 months, the PCB-fed developed chloracne, alopecia, and facial edema. 11 control treated immunized with sheep red blood cells (SRBCs) tetanus toxoid (TT). Monkeys PCB had significantly lower anti-SRBC antibody titers than controls at only two intervals following primary immunization. Antibody response to TT was not measurably affected by exposure. Both groups consistently γ-globulin levels controls. These results indicate that sustained exposure low could have modest slight immunosuppressive effects, which might be important depending on general health individual. Mice up 1000 for 3 5 weeks exhibited no signs intoxication other liver hypertrophy. However, these mice, when challenged Salmonella typhimurium , showed higher mortality greater numbers viable organisms in spleen, liver, did Similarly, exposed mice an increased sensitivity endotoxin. Thus, subclinical doses (i.e., insufficient produce overt clinical intoxication) appear impaired ability withstand challenge pathogens

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