Application of near-infrared fluorescence imaging using a polymeric nanoparticle-based probe for the diagnosis and therapeutic monitoring of colon cancer.

作者: Soon Man Yoon , Seung-Jae Myung , In-Wha Kim , Eun-Ju Do , Byong Duk Ye

DOI: 10.1007/S10620-011-1685-Z

关键词: Tumor progressionNear-Infrared Fluorescence ImagingColorectal cancerPolymeric nanoparticlesCarcinogenesisTherapeutic monitoringMatrix metalloproteinasePathologyAdenomatous colonic polypsMedicine

摘要: Background Early and accurate detection of adenomatous colonic polyps is a major concern in the prevention colon cancer. Near-infrared fluorescence (NIRF) imaging with optical probes targeting specific peptides enables noninvasive visualization characterization lesions. Matrix metalloproteinases (MMPs) are known to play an important role tumorigenesis tumor progression.

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