Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor
作者： Mark Roberge , Heldur Hakk , Gerald Larsen
DOI: 10.1016/J.TOXLET.2004.07.005
关键词: Estrogen receptor 、 Enzyme 、 Endocrine disruptor 、 Second messenger system 、 Phosphodiesterase 、 Aromatase 、 Biochemistry 、 Chemistry 、 IC50 、 IBMX
摘要: Atrazine (ATR), 2-chloro-4-ethylamino-6-isopropylamino-s-triazine, has been implicated in numerous studies to act as an endocrine disruptor, specifically by altering estradiol signaling …
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sci-hub.se 参考文章(41)
L. L. Brunton, PDE4: arrested at the border. Science Signaling. ,vol. 2003, ,(2003) , 10.1126/STKE.2003.204.PE44
Haruhiro Higashida, Kazi Z Hossain, Hiroko Takahagi, Mami Noda, Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography Analytical Biochemistry. ,vol. 308, pp. 106- 111 ,(2002) , 10.1016/S0003-2697(02)00237-3
Tammy E Stoker, Daniela L Guidici, Susan C Laws, Ralph L Cooper, The effects of atrazine metabolites on puberty and thyroid function in the male Wistar rat. Toxicological Sciences. ,vol. 67, pp. 198- 206 ,(2002) , 10.1093/TOXSCI/67.2.198
Marvin F. Grower, Anthony J. Ficara, Dorothy W. Chandler, George D. Kramer, Differences in cAMP levels in the gingival fluid of diabetics and nondiabetics. Journal of Periodontology. ,vol. 46, pp. 669- 672 ,(1975) , 10.1902/JOP.1975.46.11.669
Marie K. Tennant, D. Scott Hill, J. Charles Eldridge, Lawrence T. Wetzel, Charles B. Breckenridge, James T. Stevens, Possible antiestrogenic properties of chloro-s-triazines in rat uterus. Journal of Toxicology and Environmental Health. ,vol. 43, pp. 183- 196 ,(1994) , 10.1080/15287399409531914
Martin J. Shipitalo, Lloyd B. Owens, Atrazine, Deethylatrazine, and Deisopropylatrazine in Surface Runoff from Conservation Tilled Watersheds Environmental Science & Technology. ,vol. 37, pp. 944- 950 ,(2003) , 10.1021/ES020870B
B. Messner, J. Berndt, J. Still, Increases in rat liver cyclic AMP and glycogen phosphorylase activity caused by the herbicide atrazine. Biochemical Pharmacology. ,vol. 28, pp. 207- 210 ,(1979) , 10.1016/0006-2952(79)90505-7
Celine Mehats, Carsten B Andersen, Marcello Filopanti, S-L.Catherine Jin, Marco Conti, Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling Trends in Endocrinology & Metabolism. ,vol. 13, pp. 29- 35 ,(2002) , 10.1016/S1043-2760(01)00523-9
Jerome E. Bakke, John D. Larson, Connie E. Price, Metabolism of atrazine and 2-hydroxyatrazine by the rat. Journal of Agricultural and Food Chemistry. ,vol. 20, pp. 602- 607 ,(1972) , 10.1021/JF60181A064
Valérie Geoffroy, Françoise Fouque, Claire Lugnier, Bernard Desbuquois, Chantal Benelli, Characterization of an in vivo hormonally regulated phosphodiesterase 3 (PDE3) associated with a liver Golgi-endosomal fraction. Archives of Biochemistry and Biophysics. ,vol. 387, pp. 154- 162 ,(2001) , 10.1006/ABBI.2000.2252