A maternal low protein diet during pregnancy and lactation in the rat impairs male reproductive development
作者： E Zambrano , GL Rodriguez‐Gonzalez , C Guzman , R Garcia‐Becerra , L Boeck
DOI: 10.1113/JPHYSIOL.2004.078543
关键词: Weaning 、 Fetus 、 Offspring 、 Biology 、 Lactation 、 Birth weight 、 Pregnancy 、 Low-protein diet 、 Gestation 、 Endocrinology 、 Internal medicine
摘要: Nutrient restriction during pregnancy and lactation impairs growth development. Recent studies demonstrate long-term programming of function specific organ systems resulting from suboptimal environments fetal life development up to weaning. We determined effects maternal protein (50% control intake) and/or in rats on the reproductive system male progeny. Rats were fed either a 20% casein diet (C) or restricted (R) 10% pregnancy. After delivery mothers received C R until weaning provide four groups: CC, RR, CR RC. report findings offspring only. Maternal increased serum corticosterone, oestradiol testosterone (T) concentrations at 19 days gestation. Pup birth weight was unchanged but ano-genital distance by (P < 0.05). Testicular descent delayed 4.4 2.1 2.2 RC not related body weight. Body testis reduced RR groups all ages with exception 270 postnatal age (PN). At 70 PN luteinizing hormone T mRNA for P450 side chain cleavage (P450scc) 21 PN. Fertility rate sperm count conclude that delays sexual maturation some only emerge later life.
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