Dissection of the maternal effects on puberty onset by embryo transplantation in mouse.

摘要: Puberty onset in mammals is affected by multiple genetic and environmental factors. Among which, the maternal effect could have played a considerable role. In our previous study, we found that F1 offspring from reciprocal crosses between C3H/HeJ (C3H) C57BL/6J (B6) mice differed significantly timing of puberty both sexes, though they had identical genomic background. order to dissect causative factors such phenomenon effect, embryos were collected transplanted uterus either strain mothers, pups compared different recipient mothers egg origins. The results showed male C3H attained earlier than those B6 recipients significantly, while female did not show difference. On other hand, origin made no difference sex, yet it influenced birth weight (p<0.05). manipulation embryo transplantation delayed dramatically. A mitochondria substitution (BmC), which genome background mitochondrial hyplotype C3H, same phenotype as B6. integrated indicated uterine environment was major on differential hybrids mice.