Heterogeneity of mammalian mast cells differentiated in vivo and in vitro

摘要: The evidence for mast cell heterogeneity in vivo has grown the last several years from initial morphologic and histochemical observations to biochemical functional criteria. In species, there appear be at least two distinct classes of tissue cells that differ their content intragranular amines, proteoglycans, proteases metabolism arachidonic acid after activation. With recent discovery differentiation/growth factors vitro, it been shown a discrete subpopulation resembling one can derived culture. diversity mediators synthesized by these various populations potential functions imply may involved not only allergic responses but also other inflammatory processes, including repair growth.