Association of deworming with reduced eosinophilia : implications for HIV/AIDS and co-endemic diseases
作者： M. B. Markus , J. E. Fincham , V. J. Adams , Z. Bentwich , E. P. G. Mansvelt
DOI:
关键词: Tuberculosis 、 Albendazole 、 Trichuris 、 Eosinophil 、 Mebendazole 、 Eosinophilia 、 Immune system 、 Biology 、 Immunology 、 Deworming
摘要: 9 /l) decreased from 0.70 in the randomized trial, and 0.61 whole-school study, to well within normal paediatric range of 0.05-0.45 (P < 0.05). The prevalence eosinophilia declined 57% 37% trial (mean for 400, 800 1200 mg albendazole doses); 47% 24% study (500 stat mebendazole). Benzimidazole anthelminthics were highly effective against Ascaris but less so Trichuris. Activated eosinophils are effector immuno- regulatory leucocytes T-helper cell type 2 (Th2) immune re- sponse parasitic helminths atopic disorders. Under conditions poverty where soil-transmitted hyperendemic, Th2 polarization profile is character- istic. Regular anthelminthic treatment should reduce contact with worm antigens, this may contribute re-balancing profile. Suppression eosinophil recruitment activa- tion, together related cellular molecular immunological changes, might have positive implications prevention co-endemic diseases, including HIV/AIDS, cholera, tuberculosis
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