Respiratory atopic disease, Ascaris-immunoglobulin E and tuberculin testing in urban South African children.

摘要: Summary Background Epidemiological relation of intestinal helminth infection and atopic disease, both associated with a T-helper (Th) 2 immune response, is controversial, as it has been reported that may either suppress or pre-dispose to disease. This not tested in an area high burden Mycobacterium tuberculosis (MTB) infection, known Th1-stimulating infection. Objective To study the association disease community where endemic MTB high. Methods Three-hundred fifty-nine randomly selected children aged 6–14 years from poor urban suburb were allergy questionnaire, skin prick test (SPT) common aeroallergens, Ascaris-specific IgE (Ascaris-sIgE), fecal examination for pathogenic helminths tuberculin testing (TST). Histamine bronchoprovocation was group 10 older. Results corrected demographic variables, socioeconomic status, parental allergy, environmental tobacco smoke (ETS) exposure household, recent anthelminthic treatment clustering sampling unit. Results Ascaris-sIgE elevated 48% children, Ascaris eggs found 15% TST positive 53%. Children had significantly increased risk SPT particularly house dust mite, asthma (ever recent), rhinitis recent) atopy-related bronchial hyper-responsiveness. In negative (<10 mm), symptoms (adjusted odds ratio (ORadj) 6.5; 95% confidence interval (CI) 1.9–22.4), whereas those (10 mm) this disappeared (ORadj 0.96; CI 0.4–2.8). Conclusions These results suggest response (Ascaris-sIgE) be factor populations exposed mild protective against risk, probably by stimulation anti-inflammatory networks.