Anti-Ascaris immunoglobulin E associated with bronchial hyper-reactivity in 9-year-old rural Bangladeshi children.

摘要: Abstract Background Studies have addressed the immunomodulatory effects of helminths and their protective upon asthma. However, anti- Ascaris IgE has been reported to be associated with an increased risk asthma symptoms. We examined association between serum levels bronchial hyper-responsiveness (BHR) in children living rural Bangladesh. Methods Serum level was measured BHR test done 158 aged 9 years selected randomly from a general population 1705 Matlab Health Demographic Surveillance Area International Centre for Diarrhoeal Disease Research, investigated wheezing symptoms using questionnaire Study Asthma Allergies Childhood. tests were successfully on 152 (108 ‘current wheezers'; 44 ‘never-wheezers'). multiple logistic regression analyses. Results Of 108 current-wheezers, 59 BHR-positive; never-wheezers, 32 BHR-negative. Mean significantly higher (12.51 U A /ml; 95% confidence interval (CI), 9.21–17.00) current BHR-positive than those never-wheezers BHR-negative (3.89; 2.65–5.70; t test, p odds ratio (OR) = 7.30 [95% CI, 2.28–23.33],  = 0.001 when adjusted total IgE, Dermatophagoides pteronyssinus pneumonia history, parental asthma, Trichuris infection, forced expiratory volume one second, eosinophilic leukocyte count, sex. Conclusions Anti- is among 9-year-old Bangladeshi children.