Metal-free, highly regioselective sulfonylation of NH-1,2,3-triazoles with sodium sulfinates and thiosulfonates

作者: Raju Jannapu Reddy , Angothu Shankar , Md. Waheed , Jagadeesh Babu Nanubolu

DOI: 10.1016/J.TETLET.2018.04.023

关键词: RegioselectivityChemistryReaction conditionsArylCombinatorial chemistryMetal freeSodium

摘要: Abstract A convenient and metal-free protocol for the highly regioselective sulfonylation of NH-1,2,3-triazoles is described. range readily accessible were sulfonylated with various aryl sulfinates in presence molecular iodine. The scope was extended to thiosulfonates as an efficient sulfonylating agent nitrochromene derived triazoles also explored selective N-sulfonylation. variety synthetically viable N2-sulfonyl obtained moderate high yields excellent regioselectivities via N–S bond construction under mild reaction conditions.

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