Protein-protein interaction as biomarkers

作者: Eric B. Haura

DOI:

关键词: CancerComputational biologyProtein–protein interactionIdentification (biology)BiologyBioinformatics

摘要: The subject invention pertains to materials and methods for the classification of cancers as sensitive or resistant treatments based on protein-protein interactions, treatment cancer, identification biomarkers, interaction modulators, selection cancer treatments.

参考文章(69)
Linda Willoughby Kivi, Patrick C. Roche, Gary Gooch, Fabien Gaire, William C. Powell, Egfr antigen-binding molecules and uses thereof ,(2008)
Muhammed A Yıldırım, Kwang-Il Goh, Michael E Cusick, Albert-László Barabási, Marc Vidal, Drug—target network Nature Biotechnology. ,vol. 25, pp. 1119- 1126 ,(2007) , 10.1038/NBT1338
Melvyn S. Tockman, Prabodh K. Gupta, James L. Mulshine, Norman J. Pressman, Considerations in bringing a cancer biomarker to clinical application. Cancer Research. ,vol. 52, ,(1992)
Stephen William Watson Michnick, Brigitte Keon, Marnie Macdonald, John K. Westwick, Protein-protein interactions for pharmacological profiling ,(2005)
Ola Söderberg, Karl-Johan Leuchowius, Massood Kamali-Moghaddam, Malin Jarvius, Sigrun Gustafsdottir, Edith Schallmeiner, Mats Gullberg, Jonas Jarvius, Ulf Landegren, Proximity ligation: a specific and versatile tool for the proteomic era. Genetic engineering. ,vol. 28, pp. 85- 93 ,(2007) , 10.1007/978-0-387-34504-8_5
Frank Boschelli, Carlo Etienne, Kim Arndt, Danielle Nardin, Fei Ye, Philip Frost, Jennifer M Golas, James Gibbons, Judy Lucas, Diane H Boschelli, SKI-606, a 4-Anilino-3-quinolinecarbonitrile Dual Inhibitor of Src and Abl Kinases, Is a Potent Antiproliferative Agent against Chronic Myelogenous Leukemia Cells in Culture and Causes Regression of K562 Xenografts in Nude Mice Cancer Research. ,vol. 63, pp. 375- 381 ,(2003)
Jingchun Gao, Zhong Zheng, Bhupendra Rawal, Michael J. Schell, Gerold Bepler, Eric B. Haura, Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. Cancer Biology & Therapy. ,vol. 8, pp. 1671- 1679 ,(2009) , 10.4161/CBT.8.17.9322
Katarzyna Kowanetz, Nicola Crosetto, Kaisa Haglund, Mirko H. H. Schmidt, Carl-Henrik Heldin, Ivan Dikic, Suppressors of T-cell Receptor Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of Receptor Tyrosine Kinases Journal of Biological Chemistry. ,vol. 279, pp. 32786- 32795 ,(2004) , 10.1074/JBC.M403759200
Lori C. Kim, Lanxi Song, Eric B. Haura, Src kinases as therapeutic targets for cancer. Nature Reviews Clinical Oncology. ,vol. 6, pp. 587- 595 ,(2009) , 10.1038/NRCLINONC.2009.129
Eric B. Haura, André Müller, Florian P. Breitwieser, Jiannong Li, Florian Grebien, Jacques Colinge, Keiryn L. Bennett, Using iTRAQ Combined with Tandem Affinity Purification to Enhance Low-Abundance Proteins Associated with Somatically Mutated EGFR Core Complexes in Lung Cancer Journal of Proteome Research. ,vol. 10, pp. 182- 190 ,(2011) , 10.1021/PR100863F