Molecular Adaptors for Dye Conjugates

作者: Louis Brogley , Lubomir Sebo , Jeffrey Wegener , Gene Shen , Stephen Yue

DOI:

关键词: LinkerCombinatorial chemistryPhotochemistryFluorescenceMoleculeCyanineMoietySulfonateCarboxylateChemistryNucleic acid

摘要: In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. exemplary embodiment, dye is a polyphosphate nucleic acid adaptor. An can be component of linker. These conjugates find use in single molecule DNA sequencing and other applications. moiety cyanine dye. Cyanine highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties examples compounds invention.

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