Zero-mode waveguides for single-molecule analysis.
作者： Paul Zhu , Harold G. Craighead
DOI: 10.1146/ANNUREV-BIOPHYS-050511-102338
关键词: Fluorescence 、 Zero mode 、 Molecule 、 Fluorescence microscope 、 Fabrication 、 Small volume 、 Microscopy 、 Chemistry 、 Optoelectronics 、 Nanotechnology 、 Microfluidics
摘要: We review the optical properties, fabrication, and applications of zero-mode waveguides (ZMWs) for single-molecule studies. These simple nano-structures allow individual molecules to be isolated analysis at high concentrations. Fluorescent species are observed in a sufficiently small volume that average number fluorescent is less than one, even concentrations enough biochemical reactions proceed normal rates. Arrays such structures can also engineered into systems real-time large numbers or binding events. integration ZMWs different configurations microfluidic systems.
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