Oxidized Fat Reduces Milk Triacylglycerol Concentrations by Inhibiting Gene Expression of Lipoprotein Lipase and Fatty Acid Transporters in the Mammary Gland of Rats
作者： Robert Ringseis , Corinna Dathe , Alexandra Muschick , Corinna Brandsch , Klaus Eder
关键词: Mammary gland 、 NEFA 、 Hepatic lipase 、 Lipoprotein lipase 、 Fatty acid 、 Biochemistry 、 Biology 、 Lactation 、 Endocrinology 、 Enzyme 、 Beta oxidation 、 Internal medicine
摘要: Feeding oxidized fats to lactating rats causes a strong reduction of triacylglycerol concentration in the milk. The reason for this, however, has not yet been elucidated. Pregnant Sprague-Dawley were assigned 2 groups 11 each and fed diets containing either fresh fat (FF group) or an (OF from d 1 20 lactation. Concentrations triacylglycerols long-chain fatty acids milk weight gain suckling pups lower OF group than FF (P < 0.05). medium-chain messenger RNA (mRNA) abundance lipogenic enzymes mammary gland did differ between rats. However, had nonesterified (NEFA) plasma mRNA concentrations lipoprotein lipase acid transporters Moreover, higher hepatic lipase, transporters, several genes involved oxidation liver present findings suggest that dietary lowers by reduced uptake rich-lipoproteins NEFA into gland. study, moreover, indicates impairs normal metabolic adaptations during lactation, which promote utilization substrates synthesis
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