Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles
作者： D. L. Spector
关键词: Nuclear lamina 、 Biophysics 、 Nucleoplasm 、 Cell nucleus 、 Small nuclear ribonucleoprotein 、 Molecular biology 、 Nuclear protein 、 Immunoelectron microscopy 、 Biology 、 Lamin 、 snRNP
摘要: The structural and functional organization of the cell nucleus has been investigated using three-dimensional reconstruction, immunoelectron microscopy, high-resolution in situ autoradiography. Nuclear regions enriched small nuclear ribonucleoprotein particles (snRNPs) form a reticular network within nucleoplasm that extends between nucleolar surface envelope. snRNPs occupy approximately 18% volume CHOC 400 nuclei. sites DNA replication transcription are complementary to, rather than coincident with, concentrated snRNPs. Based on these data model mammalian is presented.
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