Analytical methods for assessing metal bioaccessibility in airborne particulate matter: A scoping review

摘要: In contrast to the existence of standardized methods assess metal bioaccessibility via gastrointestinal route, there are no widely-accepted, established in vitro testing protocols measure elemental solubility human lung. This may be attributed, part, difficulty associated with simulating lung's complex vivo conditions. The purpose this review is two-fold: (1) determine how metals ambient particulate matter (PM) lung has been assessed literature, and (2) examine suitability biological relevance applied for measurement employed date. revealed that limited attention paid development application biologically-relevant PM as a proxy Few studies (n=14) used synthetic fluids simulate conditions, only half extracting samples at temperature 37°C. There was evidence suggesting use water less effective leaching agent compared simulated fluids. sum, scoping highlights critical need develop systematic assessment respiratory route. Priority should placed on validation methods, including agents extraction parameters used, which allow conducted reliable, yet cost efficient, manner.