Changes in contractile protein mRNA accumulation in response to spaceflight.
作者： K. A. Esser , E. C. Hardeman
DOI: 10.1152/AJPCELL.1995.268.2.C466
关键词: Myosin 、 Gene expression 、 Gene isoform 、 Soleus muscle 、 Tropomyosin 、 Zero gravity 、 Troponin 、 Spaceflight 、 Internal medicine 、 Endocrinology 、 Biology
摘要: Ten rats were exposed to 9 days of zero gravity aboard the National Aeronautics and Space Administration SLS-1 space mission (June 1991). Levels fast slow isoform mRNAs from six contractile protein gene families quantified in flight soleus extensor digitorum longus (EDL) muscles. The studied myosin light chain-1 (MLC-1), chain-2 (MLC-2), troponin (Tn) T, TnI, TnC, tropomyosin. In EDL muscle there was no change mRNA levels with a general increase 23 232%. Changes seen TnCslow TnTslow increasing slightly, MLC-1slow a, b, TnIslow, alpha-Tmslow, MLC-2slow decreasing. All increased 170 1,100%. We can conclude that exposure results 1) both muscles 2) differing directional changes accumulation muscle.
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