Cytoplasm-to-myonucleus ratios following microgravity
作者： Christine E. Kasper , Lin Xun
DOI: 10.1007/BF00124357
关键词:
摘要: The cytoplasmic volume-to-myonucleus ratio in the tibialis anterior and gastrocnemius muscles of juvenile rats after 5.4 days microgravity was studied. Three groups (n=8 each) were used. experimental group (space rats) flown aboard space shuttle Discovery (NASA, STS-48), while two ground-based groups, one hindlimb suspended (suspended rats), non-suspended (control), served as controls. Single fibre analysis revealed a significant decrease cross-sectional area (μm2) forboth rats; only showed decrease. Myonuclei counts (myonuclei per mm) both significantly increased but not rats. mean myonuclear volume (individual nuclei: μm3) fibres from rats, lower than that respective control group. Estimation total (μm3 mm), however, no differences between three either or gastrocnemius. described changes myonuclei numbers resulted decreases (μm3×103) for (tibialis anterior; 15.6±0.6 (space), 17.2±1.0 (suspended), 20.8±0.9 (control): gastrocnemius; 13.4±0.4 (space) 14.9±1.1 (suspended) versus 18.1±1.1 (control)). These results indicate even short periods unweighting due to limb suspension skeletal muscle which lead ratio.
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Edward Schultz, Satellite cells in normal, regenerating and dystrophic muscle. Advances in Experimental Medicine and Biology. ,vol. 182, pp. 73- 84 ,(1985) , 10.1007/978-1-4684-4907-5_6
D. A. Riley, E. I. Ilyina‐Kakueva, S. Ellis, J. L. W. Bain, G. R. Slocum, F. R. Sedlak, Skeletal muscle fiber, nerve, and blood vessel breakdown in space‐flown rats The FASEB Journal. ,vol. 4, pp. 84- 91 ,(1990) , 10.1096/FASEBJ.4.1.2153085
E. Schultz, K. C. Darr, A. Macius, Acute effects of hindlimb unweighting on satellite cells of growing skeletal muscle. Journal of Applied Physiology. ,vol. 76, pp. 266- 270 ,(1994) , 10.1152/JAPPL.1994.76.1.266
Timothy P. White, SATELLITE CELL AND GROWTH FACTOR INVOLVEMENT IN SKELETAL MUSCLE GROWTH. Medicine and Science in Sports and Exercise. ,vol. 21, pp. S30- ,(1980) , 10.1249/00005768-198004001-00180
Edward Schultz, Marcia C. Gibson, Thomas Champion, Satellite cells are mitotically quiescent in mature mouse muscle: An EM and radioautographic study Journal of Experimental Zoology. ,vol. 206, pp. 451- 456 ,(1978) , 10.1002/JEZ.1402060314
Beth B. Krippendorf, Danny A. Riley, Temporal changes in sarcomere lesions of rat adductor longus muscles during hindlimb reloading. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 238, pp. 304- 310 ,(1994) , 10.1002/AR.1092380304
Beth B. Krippendorf, Danny A. Riley, Distinguishing unloading- versus reloading-induced changes in rat soleus muscle. Muscle & Nerve. ,vol. 16, pp. 99- 108 ,(1993) , 10.1002/MUS.880160116
Danny A. Riley, Stanley Ellis, Glenn R. Slocom, Tanjore Satyanarayana, James L. W. Bain, Frank R. Sedlak, Hypogravity-induced atrophy of rat soleus and extensor digitorum longus muscles Muscle & Nerve. ,vol. 10, pp. 560- 568 ,(1987) , 10.1002/MUS.880100612
Marcia Ontell, Muscle satellite cells: a validated technique for light microscopic identification and a quantitative study of changes in their population following denervation. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 178, pp. 211- 227 ,(1974) , 10.1002/AR.1091780206
Elward K. Alford, Roland R. Roy, John A. Hodgson, V.R. Edgerton, Electromyography of rat soleus, medical gastrocnemius, and tibialis anterior during hind limb suspension Experimental Neurology. ,vol. 96, pp. 635- 649 ,(1987) , 10.1016/0014-4886(87)90225-1